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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP4E1
All Species:
20.3
Human Site:
Y490
Identified Species:
49.63
UniProt:
Q9UPM8
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPM8
NP_031373.2
1137
127287
Y490
E
D
Q
Q
L
R
L
Y
A
V
Q
S
Y
L
T
Chimpanzee
Pan troglodytes
XP_001169245
1137
127426
Y490
E
D
Q
Q
L
R
L
Y
A
V
Q
S
Y
L
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535479
1138
127884
Y490
E
D
Q
Q
L
R
L
Y
A
V
Q
S
Y
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q80V94
1122
124787
Y489
E
D
Q
Q
L
R
L
Y
A
V
Q
S
Y
L
T
Rat
Rattus norvegicus
P18484
938
104026
S314
A
V
L
F
E
A
I
S
L
I
I
H
H
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_699042
1121
123888
Y483
E
D
D
Q
L
R
L
Y
A
V
D
S
Y
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91926
940
105602
L316
V
L
F
E
A
I
N
L
I
I
H
S
D
S
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328755
980
107167
S356
L
G
R
L
I
K
L
S
P
E
I
A
E
Q
H
Maize
Zea mays
NP_001169710
969
105519
G345
S
H
N
L
K
Y
M
G
I
D
A
L
G
R
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12028
832
93606
L208
K
I
I
Q
S
I
L
L
I
G
L
N
R
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
91.7
N.A.
79.9
20.7
N.A.
N.A.
N.A.
N.A.
54.1
N.A.
21.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
N.A.
95.5
N.A.
87.6
41.1
N.A.
N.A.
N.A.
N.A.
71.6
N.A.
42.2
N.A.
N.A.
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
N.A.
N.A.
N.A.
86.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
N.A.
N.A.
N.A.
86.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
31.4
30.4
N.A.
N.A.
20.9
N.A.
Protein Similarity:
49
48.7
N.A.
N.A.
38.6
N.A.
P-Site Identity:
6.6
0
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
33.3
6.6
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
10
10
0
0
50
0
10
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
50
10
0
0
0
0
0
0
10
10
0
10
10
0
% D
% Glu:
50
0
0
10
10
0
0
0
0
10
0
0
10
0
10
% E
% Phe:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
10
0
10
0
0
10
0
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
10
10
10
0
10
% H
% Ile:
0
10
10
0
10
20
10
0
30
20
20
0
0
0
0
% I
% Lys:
10
0
0
0
10
10
0
0
0
0
0
0
0
10
10
% K
% Leu:
10
10
10
20
50
0
70
20
10
0
10
10
0
50
10
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
10
0
0
0
0
10
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% P
% Gln:
0
0
40
60
0
0
0
0
0
0
40
0
0
10
0
% Q
% Arg:
0
0
10
0
0
50
0
0
0
0
0
0
10
10
0
% R
% Ser:
10
0
0
0
10
0
0
20
0
0
0
60
0
10
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% T
% Val:
10
10
0
0
0
0
0
0
0
50
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
50
0
0
0
0
50
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _